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Construction and evaluation of an average CT brain image for inter-subject registration.

Jongen C, Pluim JP, Nederkoorn PJ, Viergever MA, Niessen WJ

Image Sciences Institute, University Medical Center Utrecht, Room E01.335, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands. cynthia@isi.uu.nl

An average CT brain image is constructed to serve as reference frame for inter-subject registration. A set of 96 clinical CT images is used. Registration includes translation, rotation, and anisotropic scaling. A temporary average based on a subset of 32 images is constructed. This image is used as reference for the iterative construction of the average CT image. This approach is computationally efficient and results in a consistent registration of the 96 images. Registration of new images to the average CT is more consistent than registration to a single CT image. The use of the average CT image is illustrated.

Published 2 November 2004 in Comput Biol Med, 34(8): 647-62.
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