Stroke Research Today is a free monthly online journal that collates and summarizes the latest research about Stroke, including details on treatment, recovery, rehabilitation, signs, symptoms.

Diagnosis of middle cerebral artery occlusive lesions with contrast-enhanced transcranial color-coded real-time sonography in acute stroke.

Ogata T, Kimura K, Nakajima M, Naritomi H, Minematsu K

Cerebrovascular Division, Department of Medicine, National Cardiovascular Center, Japan. togata@intmed2.med.kyushu-u.ac.jp

It is useful to evaluate the occlusive lesions of middle cerebral artery (MCA) occlusion with transcranial color-coded real-time sonography (TCCS). However, TCCS criteria for locating the site of the MCA occlusion has, as yet, remained unclear. The aim of the present study was to establish TCCS criteria for MCA occlusive lesions. We prospectively performed contrast-enhanced TCCS (CE-TCCS) in 75 consecutive acute stroke patients within 24 h of digital subtraction angiography. Patients were divided into four groups: occlusion of the MCA stem (MO group, n=12); occlusion of the MCA branch (MBO group, n=10); stenosis of the MCA stem (MS group, n=9); and no occlusive or stenotic lesions (control group, n=44). The following parameters were measured: peak systolic velocity (PSV) and end diastolic velocity (EDV) of bilateral MCA stems, and ED-ratio (the side-to-side ratio of the EDV). We establish the CE-TCCS criteria for MCA occlusive lesions using the sensitivity-specificity curve analysis. A PSV of 170 cm/s distinguished MCA stenosis from other groups (positive and negative predictive values and the accuracies were 100%, 99.0% and 99.1%, respectively). An EDV of 26 cm/s differentiated MO or MBO from the other groups (positive and negative predictive values and the accuracies were 84.6%, 100% and 96.5%, respectively). An ED-ratio of 2.5 discriminated MO from the MBO group (positive and negative predictive values and the accuracies were 88.9%, 85.7% and 87.5%, respectively). Measurement of MCA stem flow velocity with CE-TCCS can identify MCA stem stenosis and occlusion, as well as MCA branch occlusion.

Published 2 May 2005 in Neuroradiology, 47(4): 256-62.
Full-text of this article is available online (may require subscription).

© 2004-2008 Stroke Research Today. All Rights Reserved.