Stroke Research Today is a free monthly online journal that collates and summarizes the latest research about Stroke, including details on treatment, recovery, rehabilitation, signs, symptoms.

A randomized, placebo-controlled study of donepezil in poststroke aphasia.

Berthier ML, Green C, Higueras C, Fernández I, Hinojosa J, Martín MC

Centro de Investigaciones Médico-Sanitarias, University of Malaga School of Medicine, Spain. mberthier@terra.es

We studied 26 patients in a randomized, placebo-controlled, double-blind parallel trial to evaluate the efficacy and safety of donepezil in chronic poststroke aphasia. Donepezil (10 mg/day) improved aphasia severity at endpoint (week 16) relative to placebo (p = 0.037).

Published 14 November 2006 in Neurology, 67(9): 1687-9.
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