Stroke Research Today is a free monthly online journal that collates and summarizes the latest research about Stroke, including details on treatment, recovery, rehabilitation, signs, symptoms.

Encephalopathy, stroke, and myocardial infarction with DMSO use in stem cell transplantation.

Chen-Plotkin AS, Vossel KA, Samuels MA, Chen MH

Department of Neurology, Massachusetts General Hospital and Brigham and Women's Hospital, Boston, MA 02115, USA. aschen@partners.org

Stem cell transplants are established therapy for hematologic and solid tumor malignancies. Known neurological complications of stem cell transplantation include CNS infection, seizures, strokes, metabolic encephalopathy, and hemorrhage. We report two cases of autologous stem cell transplantation complicated by cerebral infarction and myocardial injury. We postulate that the cryopreservative dimethyl sulfoxide may be responsible.

Published 13 March 2007 in Neurology, 68(11): 859-61.
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